Through my research I have established specific brain regions and pathways involved in generation of anxiety and depression. I have also established several animal models of stress and resilience. Over the years I have shown that growth of neurons in amygdala, the emotional center of brain is correlated with high anxiety. Additionally, I have shown through gene therapy approach that manipulation of certain proteins within the amygdala can block both neuronal growth and correlated anxiety. Recently I have shown another very different approach, i.e., manipulation of environment alone can reduce stress-related symptoms. All these approaches indicate the amazing malleable nature of brain and behavior. This also holds up the promise that through proper therapeutic intervention that targets specific plasticity of brain, we can arrive at more definitive medicines and curative approaches.